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HPU (hemopyrollactamuria) or the no longer correct term KPU (cryptopyrolluria) characterize a genetic, i.e. congenital, porphyrinopathy. I first came across the condition many years ago when I was researching ADD and ADHD. HPU belongs to the clinical picture of porphyrias, which are caused by a genetic enzyme disorder.

This disorder affects the synthesis of hemoglobin (red blood pigment). In severe cases, this leads to blood disorders. Mild cases suffer from psychological discomfort before some.

These include ADD (Attention Deficit Disorder), ADHD Attention Deficit Hyperactivity Disorder, depression, anxiety, joint pain, pale skin especially on the face, facial swelling, muscle spasms, white spots on the nails, soft enamel, hair loss, sensitivity to light, being easily exhausted, allergies, fertility disorders, medication and chemical intolerance, lack of dream memory, headaches, migraines, menstrual problems, susceptibility to infections, edema, heart and vascular diseases. What is important here is the differentiation from clinical pictures with similar symptoms, such asMCS(multiple chemical sensitivity) andmitochondrial disease. HPU leads to increased excretion of vitamin B6. Vitamin B6 is an important factor in the formation of vitamin B3 and picolinic acid. The latter is involved in the absorption of minerals such as chromium, zinc, manganese and magnesium. So there is a lack of this mineral as well as vitamin B6 and B3. It used to be thought that the genetic disorder was rare. Improvements in testing methods have demonstrated a frequency of 5% in males and 10% in females. MCS cannot always be classified as a clinical picture independent of HPU, since HPU also disrupts the cytochrome P-450 detoxification system of the liver. Occasionally, the appearance of HPU is triggered by stress, medication, chemicals, or infection. The KEAK (clinical ecological allergy center) determined in the evaluation of numerous data that gluten hypersensitivity and occasional reactions to casein and soy protein can often be observed in HPU sufferers. At the same time, there is an excess of copper, which can cause reduced histamine levels by activating the histamine degradation enzymes MAO and DAO. However, this is not always the case. Children and adolescents often have low blood sugar levels and adults develop diabetes mellitus. Adrenal disorders are common in HPU. The adrenal glands are important for the release of many hormones and especially the stress hormones adrenaline, noradrenaline and cortisone. So that it can also be explained why HPU patients have a reduced stress tolerance. Mental illnesses should also be screened for HPU. The lack of trauma separation can be improved by the administration of zinc. However, if too much zinc is prescribed or given in the evening, intense dreams can occur, resulting in sleep disorders. A careful approach to dosing supplements is therefore necessary.

Recommended book on HPU by Dr. John Kammsteg, in which some passages are mine, I show you here:

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